Abstract
Summary
1. A virus (Mack) has been isolated in vitro from a patient's feces previously reported as containing poliomyelitis virus of very limited pathogenicity for monkeys. The virus is immunologically distinct from poliomyelitis, and does not produce pathognomonic lesions of poliomyelitis in monkeys. The patient failed to develop a rise of poliomyelitis neutralizing antibodies in convalescence. 2. The virus has been cultivated in monkey and human tissue cultures in which is produced fibroblastic degeneration morphologically indistinguishable from that caused by prototype poliomyelitis viruses. Suckling and adult mice are unaffected as are guinea pigs, rabbits, and hamsters. 3. The donor of the virus was a febrile child with pleocytosis who developed specific neutralizing antibodies in high titer in convalescence. Similar antibodies have been detected in adult sera and in a pool of human gamma globulin.
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