Abstract
Conclusions
1. Growth hormone causes a marked reduction in urinary nitrogen output in the fasted phlorhizinized normal rat but does not have this effect in either the phlorhizinized adrenalectomized or the unphlor-hizinized normal or adrenalectomized animal. 2. In view of the ketogenic effect of growth hormone in the normal fasted rat and the absence of this effect in either the adrenalectomized, the phlorhizinized normal or phlorhizinized adrenalectomized rat the hypothesis is advanced that the ketogenic action of growth hormone is independent of its nitrogen retaining action and apparently requires the presence of the adrenal cortex for its appearance. 3. Growth hormone caused a marked reduction of glycosuria in the phlorhizinized fasted rat. This together with the reported increased glycosuria of alloxanized or ACTH treated rats after growth hormone lead to the conclusion that the diabetogenic action of growth hormone is indicative of a relative preponderance of the inhibitory action of growth hormone on peripheral glucose uptake over its action in reducing gluconeogenesis from protein in the liver.
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