Renal Function During Viomycin ∗ Administration to Dogs

Abstract

Summary

Daily doses of 15-60 mg/kg of Viomycin administered for a period of 6 months did not appear to produce any evidence of renal toxicity as estimated by renal function studies (clearances). There were no serious alterations of the concentrations of serum sodium and potassium. These data suggest that the renal toxicity and altered electrolyte metabolism associated with Viomycin therapy may not be as serious as the earlier observations indicated. Therefore, we believe that further use of Viomycin with careful observations for signs of renal toxicity is indicated, particularly in patients unresponsive to the other more effective therapeutic approaches.