Influence of Administration of ACTH on Urinary Amino Acids ∗

Abstract

Summary

Typical results are presented showing the influence of ACTH a dministration in the human on the urinary excretion of nitrogenous substances. The hormone evoked notable increases in the excretion of amino acids, ammonia, urea, uric acid, and some undetermined nitrogenous constituents. Twodimensional chromatograms revealed some of the detailed changes in the excretion of both free and bound amino acids. Microbiological determination of some of the amino acids gave results which were concordant with the chromatographic findings. All of the urinary nitrogenous constituents returned to normal levels shortly after cessation of the treatment. The possible significance of some of the findings is indicated.