Abstract
Conclusions
1. The recovery of gentisic acid and salicylate were similar, approximating 62 and 68% respectively of the administered drugs, and 84 and 88% respectively, following alkalinization. 2. Alkalinization increased the combined and free forms of gentisic acid eliminated but did not alter their relative proportions. 3. The amount of gentisic acid recovered from salicylate administration was increased with alkalinization without alteration in the proportion of free to combined gentisic acid obtained with salicylate alone. 4. Whereas the free gentisic acid represented approximately 42% of the total gentisic acid recovered when administered alone, the amount of free gentisic acid obtained from salicylate administration represented approximately 10% of the total genetisic acid. 5. Acidification with dilute hydrochloric acid, but not ammonium chloride decreased the total excretion of gentisic acid at the expense of the combined, the free remaining unaltered. 6. Acidification with both dilute hydrochloric acid and ammonium chloride decreased the total excretion of salicylate and the combined gentisic acid metabolite, the proportion of free to combined gentisic acid remaining unaltered.
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