Electrophoretic Studies on Cerebrospinal Fluid. ∗

Abstract

Summary

1. The results of a detailed investigation of the distribution of two rapidly migrating components and of other protein components of cerebrospinal fluids have been presented. A component (X-protein) migrating about 20% faster than the albumin could be demonstrated in every fluid by electrophoresis in phosphate at pH 7.85 and ionic strength 0.05. In addition a component (X₁) migrating 8-14% faster than the X-protein was observed in 20% of the cases. 2. Analyses of 49 patterns of the most frequently encountered type and 16 atypical patterns are presented. No individual protein component was responsible for the higher protein concentration observed in some of the fluids. A possible relationship between the X₁ component and the occurrence of convulsion in patients was indicated.

The authors wish to acknowledge the cooperation of Dr. W. O. Klingman and his associates of the Neurology Clinic; the staff of the Neurosurgery Clinic and the staff of the Roanoke Veterans Hospital for supplying the cerebrospinal fluids.