Abstract
Summary
Using Cr51 as the tracer, chromic chloride was administered intravenously to rats and rabbits for distribution studies. At the end of 24 hours up to 40% was excreted by the kidneys, while the greatest concentration of Cr51 occurred in the bone marrow. It is suggested that in addition to binding with plasma proteins, the trivalent chromium deposits in the reticulo-endothelial system in a pattern similar to that of small size colloids of a slow clearing nature. The Cr51 in the sites of localization appeared to be bound to protein.
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