Abstract
Summary
1. Hyaluronidase or testicular extract enhances the lesions produced in non-immunized and passively immunized rabbits following intradermal inoculation of vaccinia virus. 2. On the contrary, in rabbits with a partial active immunity the lesions induced by the virus are partially suppressed by the spreading effect of hyaluronidase. 3. When the reactions of the rabbits are expressed in terms of the ratio of the diameter of the lesions of the saline series of virus dilutions to the diameter of the hyaluronidase or testicular extract series, the ratios are 0.60, 0.67, and 1.18 for the non-immunized, the passively immunized, and the partially, active immune groups of rabbits, respectively.
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