Abstract
Summary
1. When dogs which had been subjected to severe hemorrhage were treated within 30 minutes with 50 to 100 mg/kg of 1 -ethanesulfonyl-4-ethyl-piperazine administered intravenously, survival time was prolonged or mortality decreased in comparison to untreated control animals. 2. No protective action was evident when treatment was withheld until there had been 90 minutes of hypotension. 3. The piperazine compound is definitely toxic and was considered responsible for death of 3 of 30 dogs in which it was used for treatment. 4. The drug imposed a decided hypotensive factor on the acute 40 mm Hg state produced deliberately by controlled hemorrhage.
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