Abstract
Summary
1. Mice were infected with group A streptococci and treated with chloramphenicol and penicillin, separately and in combination. Jawetz's observation that chloramphenicol interfered with penicillin when animals were given a single aqueous injection of both antibiotics was confirmed. 2. The interference was not demonstrable, however, when antibiotic blood levels were maintained for 2 or 3 days. Thus, despite early interference, the combination caused a progressive bactericidal action which, in conjunction with phagocytosis, protected the mice as well as penicillin alone. 3. These experiments imply that the phenomenon of antibiotic interference is seldom of clinical significance.
Get full access to this article
View all access options for this article.