Abstract
Conclusions
1. These data contribute to the importance of niacinamide derivatives as a new class of antituberculosis agents. One of these, pyrazinoic acid amide, is active when administered by parenteral or oral route. Under suitable experimental conditions, pyrazinoic acid amide is more active than para-aminosalicylic acid; the activity of pyrazinoic acid amide as compared with para-aminosalicylic acid increases when the average survival time for infected controls is prolonged. 2. The in vitro inhibitory concentration for M. tuberculosis, human type, strain H37Rv, tested in Dubos'Tween-Albumin medium, is 150γ/ml. Resistance develops rapidly in vitro; the inhibitory concentration rises to more than 1000 γ/ml after 3 serial bi-weekly transfers.
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