Abstract
Summary
1. Measurements have been made of the resistance offered by the skin to the intracutaneous introduction of fluid, as determined by the amount of pressure required to perform an intracutaneous injection under carefully controlled conditions in adult male rats. 2. Systemic administration of cortisone markedly increased the resistance of the skin to injection. Hyaluronidase, incorporated in the fluid administered intracutaneously, lowered the injection pressure. The effect of cortisone, however, was shown to be independent of the effect of the steroid upon hyaluronidase. Testosterone, desoxycorticosterone, compound S, and 21-acetoxypregnenolone were without effect under the conditions of these experiments.
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