Abstract
Summary
(1) The hyperemia and edema of an hyperergic reaction-induced by an intraperitoneal injection of dextran or egg-white in rats—can be topically inhibited by a preceding local inflammation. (2) The degree of this “topical protection phenomenon” depends on the intensity of the preceding inflammation. (3) The preceding inflammation was produced in the paw by a subcutaneous injection of small doses of dextran, egg-white, peptone or hyaluronidase. The phenomenon is therefore considered to be non-specific. (4) Under our experimental conditions the protection phenomenon reached its maximum 38 hours after induction of the first inflammation, and disappeared in the course of approximately 5 days after the first inflammation.
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