Abstract
Summary
1. ACTH activity disappears rapidly from neutral aqueous, 0.9% sodium chloride, or basic extracts of pituitary. Activity is stable in weak hydrochloric acid extracts of the gland. ACTH prepared by the acid-acetone technic(3) or a modification of same (4) is unstable in water; sodium phosphate and sodium chloride exert a stabilizing influence on biological activity. Purified ACTH is stable in weak hydrochloric acid solution. 2. Under the experimental conditions employed we have been unable to confirm the claim of Li that ACTH is “activated” by heating in weak hydrochloric acid solution.
Get full access to this article
View all access options for this article.