Abstract
Conclusions
(1) When a mixture of mumps virus with specific immune serum was injected into the eyes of guinea pigs, the serum completely prevented the corneal reaction and the production of complement fixing antibodies. Pooled sera collected from normal mumps susceptible children, when mixed with mumps virus and injected into the eyes of guinea pigs irregularly prevented the corneal reaction and the production of complement fixing antibodies. (2) Subsequent to the injection of mumps virus into the eye of the guinea pig, complement fixing antibodies appear in the convalescent sera between the 4th and 8th day, persist at significant levels until the 20th to 24th days, and then decline. (3) Mumps virus persists or grows in guinea pig eyes for at least 8 days after inoculation. (4) Chick embryo adapted strains of mumps virus recently recovered from parotid tissue, saliva and testicular fluid when injected into guinea pig eyes produce the corneal reaction, and complement fixing antibodies were demonstrated in the convalescent sera.
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