Beneficial Effects of Liver on Cortisone Acetate Toxicity in the Rat. ∗

Abstract

Summary

The administration of toxic doses of cortisone acetate to immature rats maintained on a synthetic diet resulted in retarded growth, alopecia and death. These effects were largely counteracted by the administration of desiccated whole liver when fed at a level of 10% of the diet. The protective factor(s) in liver was distinct from any of the known B vitamins.