Abstract
Summary
The compounds, 3–chloromer–curi–2–methoxypropylurea (1347Ex), 3–car–boxymethylmercaptomercuri − 2 – methoxypro–pylurea (1353 Ex), and. 3 – (α–carboxye thylmer–captomercuri) − 2 –methoxypropylurea (1431–Ex), had 3 or 4 times the diuretic potency of meralluride in the dog. Twenty–four and 48 hour mercury excretion rates were comparable to that of meralluride at the same dosage level. Chronic toxicity studies indicated no essential difference between meralluride and the other compounds, if the greater diuretic potency of the new compounds was considered and the dosage adjusted accordingly. Large amounts of 1353Ex and 1431 Ex were infused intravenously without disturbing cardiac function, but the acute cardiac toxicity of 1347Ex, although greater than the other 2 compounds, appeared to be less than meralluride.
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