Abstract
Summary and conclusions
1. The resistance to the Shwartzman phenomenon which develops when the reaction is elicited at short intervals is transient, disappearing after a rest period of 21-28 days. 2. This resistance was found to be effective against Shwartzman active materials from heterologous bacterial species. 3. It was found that a transient state of non—reactivity could be produced by repeated inocuilation of bacterial substances intracutaneously, intravenously or intramuscularly, evidence that the resistance is not depeneded on the development of skin hemorrhage. 4. The resistance which develops by repetitive injections could be overcone by in creasing the provocative intravenous dose but not by increasing the preparatory intracutaneous dose. 5. Attempts to transfer this resistance passively with homologous serum were unsuccessful.
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