Abstract
Summary
1. Chloramphenicol inhibited the growth of primary atypical pneumonia virus in chick embryos when injected into the yolk sac as a single dose of 5 mg one hour after amniotic inoculation of virus. Less definite inhibition of the growth of this virus in chick embryos was observed with two derivatives of 5-nitro-2-furaldehyde semicarbazone. 2. Cotton rats infected intranasally with the virus of atypical pneumonia were treated by intraperitoneal injection of several different cyclic aldehyde semicarbazone and thiosemicarba—zone derivatives. Most marked suppression of the pulmonary lesions was obtained with substituted 5-nitro-2-furaldehyde semicarba—zones, p-nitrobenzaldehyde semicarbazone, and p-acetylaminobenzaldehyde thiosemicarbazone.
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