Abstract
Summary
An agglutinin is described which exists in most normal sera and which is capable of agglutinating trypsin modified erythrocytes. By virtue of such action, it resembles the agglutinins active against erythrocytes altered by bacterial filtrates, viruses, and periodate ions. Undiluted serum or serum in weak dilution is able to reverse the activity of this agglutinin. Such a reversal effect is mediated through an altered reactivity of the trypsin treated erythrocytes with respect to the agglutinin described above. No modification of the reactivity of the cells with respect to other agglutinins has been noted. The effect of various physical and chemical agents on the activity of the agglutinin and the agglutination reversal effect is described and the patho-physiological role of the agglutinin is discussed.
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