Effect of Hydrolytic Products of Procaine on Procaine Toxicity and Metabolism in Mice

Abstract

Summary

The subcutaneous LD₅₀s of 25% PABA, 5% DEAE, and 5% DMAE in mice were found ito be 4.39, 1.61, and 2.08 g/kg respectively. Subcutaneous premedication by l g/kg of 7% PABA did not alter the LD₅₀ of intravenous procaine in mice, while subcutaneous premedicatlion by 0.5 g/kg of either 5% DEAE or 576 DMAE lowered the LDSO about 35%. Neither PABA, DEAE, nor DMAE changed the rate of disappearance of procaine from the whole body of the mouse. It is concluded that the influence observed to be exerted by DEAE and DMAE on the toxicity of intravenous procaine is probably due to their additive toxic effects on the cardio-vascular system, and not to the inhibition of procainesterase in vivo.