Abstract
Summary
The intravenous administration of hypercholesterolemic rabbit plasma in normal rabbits resulted in a rapid increase in total serum cholesterol followed by a gradual decrease. The highest value was obtained in 5 minutes and in 6 hours or less the total serum cholesterol had reached the lowest post-injection level. In 24 hours, the total serum cholesterol was significantly increased above the 6 hour level with no significant alteration in the E/F ratio. Rabbits receiving normal rabbit plasma, normal saline or no injection showed little alteration in the total serum cholesterol for 6 hours. In 24 hours, the total serum cholesterol likewise increased significantly compared to the 6 hour level. The rise in total cholesterol at 24 hours is apparently related to the mechanics of performing the experiment rather than to the injection of cholesterol.
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