Abstract
Summary
An analog of pantothenic acid, the sodium salt of N(α, γ-dihydroxy-β,β-di-methylvaleryl) β-alanine (termed ω-methylpantothenic acid) has been found to prevent pantothenic acid deficient rats from responding normally to calcium pantothenate as measured by an acetylation test using sulfanilamide. When 140 mg of the analog were administered over a period of 3 days only a small response was noted; 230 mg over a sixday period prevented any response. After the analog was withdrawn and pantothenic acid administered, the animals exhibited a marked increase in acetylation.
Get full access to this article
View all access options for this article.