Toxicity and Effect of ω-Methylpantothenic Acid on Blood-Induced Infections of Plasmodium Lophurae in the Chick. ∗

Abstract

Summary

ω-Methylpantothenic acid has been shown to exhibit low acute toxicity toward rats, mice and chicks. Growth inhibition of Tetrahymena geleii H at high levels of this analog was reversed by pantothenic acid. Plasmodium lophurae infections in chicks on the other hand were unaffected by ω-methylpantothenic acid administered intraperitoneally at a level of 2 g/kg twice daily for 4 days or orally at 5 g/kg daily for 5 days. In chicks on a pantothenic acid-deficient diet, the simultaneous administration of ω-methylpantothenic acid did not alter the course of the infection with P.lophurae.