Abstract
Summary
The subcutaneous administration of testosterone propionate depressed the rise in urinary nitrogen excretion following burns in male and female rats. The effect of testosterone propionate in reducing the total urinary nitrogen excretion of male and female adult rats is essentially unchanged by a thermal burn for a period of 8 days after the burn or onset of the testosterone medication. For 2 to 4 days after this period the effect of the drug post-burn is no longer evident. In normal female animals the effectiveness of testosterone propionate continues for at least 18 days whereas in normal males it disappears at 12 to 14 days. Possible reasons for this wearing-off of the effectiveness of testosterone propionate after burns are considered. Various problems connected with the possible use of testosterone. propionate in the damaged patient are discussed.
A part of this report is based on work done by Capt. Braasch in the Department of Physiology of the University of Illinois School of Medicine in partial fulfillment of the requirements for the degree of Master of Science in Physiology. The authors wish to thank the Schering Corporation for a generous supply of testosterone propionate.
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