Abstract
Summary and Conclusions
1. Chick embryo-adapted mumps virus has been shown to infect the tissues of the guinea pig's eye after intraocular inoculation.
2. Mumps virus has been carried through 7 successive guinea pig passages by intraocular injection with the subsequent production of complement-fixing antibodies in the sera of guinea pigs in passages I, II and VII. A virus culturally and immunologically indistinguishable from the original virus has been recovered from ocular tissue of passages V, VI and VII by inoculation into chick embryos.
3. When doses of virus 6 to 10 times as large as those necessary to infect the anterior chamber were introduced into the plantar spaces, peritoneal cavity, or heart, antibody formation was low or absent as shown by titers of the complement fixing antibody in the convalescent sera.
4. The guinea pig appears to be a suitable animal for the study of mumps virus infections when inoculations are made into the anterior chamber of the eye.
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