Influence of Blood Incompatibilities on Measurement of Blood Volume by Cell-Tagging Methods. ∗

Abstract

Summary

A study of the blood volume of the dog as measured simultaneously by the Dye T-1824, by carbon monoxide and by radioactive iron, Fe₅₅, has shown that the values measured by the cell-tagging methods are distinctly lower than the value given by the dye method whenever the donor blood tagged with CO or Fe₅₅ shows incompatibility with the blood of the recipient animal. However, when the bloods of the donor and the recipient animals show no incompatibility, the results by the three methods show improved agreement. These results suggest that the cell-dumpings occurring in the reaction of incompatibility, by making the smaller vessels inaccessible to the clumped cells, reduce the volume measured by the tagged cells.