Metabolism of C 13 -Carboxyl-labeled Malonate by the Intact Mouse ∗

Abstract

Summary

When C¹³ - carboxyl - labeled malonate was injected subcutaneously into mice, 20-32% of the labeled carbon was recovered in the respiratory carbon dioxide in 6 hours.

At body temperature, dog plasma showed little or no ability to decarboxylate malonate.

These results are interpreted to indicate the probable occurrence in mammalian cells of enzymatic mechanisms for conversion of malonate to carbon dioxide.