Abstract
Summary
Phenindamine (Thephorin) was determined in biologic material with a high degree of specificity by a modification of the Brodie methyl orange technic. Negligible amounts of phenindamine can be recovered in the urine of humans following oral administration. In studies on rats the compound appears to be rapidly absorbed from the gastrointestinal tract. The compound rapidly leaves the blood and concentrates in tissues. High concentrations of the drug were found in the lungs, liver, kidneys and brain. Extensive accumulation of phenindamine did not occur after repeated administration of the compound twice daily for 4 consecutive days. It is concluded that the compound is metabolized to a considerable extent in the body since less than 12 per cent of the total dose of phenindamine could be recovered unchanged in the urine and feces 24 hours following oral administration.
We are grateful to the American Allergy Foundation and the Division of Research Grants, National Institutes of Health, U. S. Public Health Service, for generously supporting our studies, to Dr. E. L. Sevringhaus of Hoffman-La Roche, Inc., for supplying the samples of Thephorin, and to Dr. P. K. Smith for his comments and advice.
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