Abstract
Summary
The study provides evidence that Compound A (11-dehydrocorticosterone acetate) has pronounced biological activity. Among these is the ability to reduce the size of: (1) the adrenal glands, (2) tissues related to the lymphoid system and, (3) possibly the accessory reproductive organs. The life expectancy of mice bearing transplantable lymphatic leukemia PI 534 was increased and evidence of modification of the local lymphatic lesion was observed. Growth of the tumor mass of lymphosarcoma 6C3HED was prevented for a short experimental period.
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