Abstract
Summary and Conclusions
1. Pellets of crystalline tocopherol esters (d-alpha-tocopheryl palmitate, phosphate, or succinate and d-delta-tocopheryl phosphate) were implanted into the subcutaneous tissue over the dorsal shoulder region of male and female mice. A solution of mixed natural tocopherols was injected into the same region in other animals.
2. All the tocopherol preparations produced local tissue changes resembling a foreign body reaction. Qualitatively, alpha-tocopheryl palmitate and mixed natural tocopherol concentrate produced slight local reaction, The reaction to alpha-tocopheryl succinate and delta-tocopheryl phosphate was greater, and that to alpha-tocopheryl phosphate the most pronounced.
3. All the tocopherol preparations maintained gestation in tocopherol-deficient mice.
4. Two of the alpha-tocopheryl succinate and the alpha-tocopheryl palmitate preparations produced intermittent or continuous vaginal cornification.
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