Abstract
Summary and Conclusions
SC 1950 has a profound effect on the peripheral circulation. A fall of blood pressure is observed in normal individuals as well as in patients with peripheral vascular disease, but in the latter group this response is subject to considerable variations. The pulse rate is frequently elevated, and considerable variations occur following intravenous injection of SC 1950. The pulse volume of the digits shows a marked increase in normal individuals, is somewhat less in patients with moderate peripheral arterial disease, and varies only insignificantly in patients with advanced organic peripheral arterial disease. In normal individuals the skin temperature of the digits rises sharply, often as much as 8°C, while little change is observed in patients with advanced peripheral disease. Digital blood flow in normal individuals shows a marked increase, while it rises only slightly in patients with moderate or advanced peripheral arterial disease. In all groups the fall in systolic pressure is greater than that in diastolic pressure. From these observations it may be concluded that SC 1950 is an effective spasmolytic agent, capable of increasing the blood flow to the periphery, but beset by a number of side reactions upon intravenous as well as rectal administration.
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