Abstract
Summary
In the early stages of alloxan diabetes in the rabbit there may or may not occur a transitory hyperlipaemia in which all of the serum lipid constituents, but especially the neutral fat, are elevated. In a few cases the hyperlipaemia may persist for an indefinite period of time. This elevation of serum lipids is apparently due to mobilization of fat from the tissue fat depots and is related to the severity of the diabetes. In the normal rabbit only a small proportion of the lipid phosphorus and the total and free cholesterol is “readily extractable”; in the hyperlipaemic serum of the alloxan diabetic rabbit a much greater proportion of these lipid constituents is “readily extractable”. It is suggested that in the normal rabbit much of the lipid phosphorus and cholesterol of the serum is bound to the serum proteins, while in the hyperlipaemia of alloxan diabetes in the rabbit the increase of these lipids is principally in the fractions not closely associated with the serum proteins.
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