Anesthetic Properties of Procaine Amide (Pronestyl) and Other Amide Analogues of Local Anesthetic Compounds. ∗

Abstract

Conclusions

1. The anesthetic potencies of three anesthetics and their amide analogues have been determined and compared.

2. The amide analogues are relatively ineffective as anesthetics upon intact nerve trunks.

3. The partition coefficients between Ringer's solution and chloroform and between buffered isotonic saline of these anesthetics and their amide analogues have been determined.

4. The differences in partition coefficients between these anesthetics and their amide analogues and their pharmacological actions have been discussed.