Abstract
Conclusion
Mice of strain A orchidectomized before weaning and bearing grafts of anterior hypophysis, of ovaries, or of anterior hypophysis together with ovaries from the age of one month on, developed malignant lymphoid tumors. Anterior hypophysis seems to exert its leukemogenic effect (1) through the ovaries and (2) independently of the grafted ovaries, possibly through the adrenal cortex. Transplantation of ovaries together with anterior hypophysis resulted in the highest incidence of malignant lymphomas. The age factor plays in this type of leukemogenesis a less important role than in the production of mammary cancers by anterior hypophyseal and ovarian grafts.
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