Tissue Distribution and Elimination of DDD and DDT Following Oral Administration to Dogs and Rats. ∗

Abstract

Conclusions

1. DDD and DDT when administered orally are stored in the tissues of the dog, the greatest storage appearing in the fat.

2. Similarly DDD and DDT are both stored in the fat of the rat.

3. Both DDD and DDT are transported across the placental barrier in the dog.

4. In the dog, a small proportion of orally administered DDD or DDT is excreted in the feces. Of the 2, DDD appears in greater amount.

5. When administered orally to the dog, neither DDD nor DDT are excreted as such in the urine. DDA is a urinary end-product common to both DDD and DDT, appearing in greater amount following DDD administration.

We wish to extend our thanks to Dr. E. L. Stanley of the Rohm and Haas Company for performing the analytical procedures connected with this study.