Abstract
Summary
Based on the determination of radioactivity for periods of 10, 20, 30, and 40 minutes following a subcutaneous injection of 10 mg/kg of C-14 labelled methadone HBr into rats, it was found that:
(a) Methadone∗ makes its appearance in the blood within 10 minutes, and is confined to the plasma.
(b) There was no activity in the cerebrum before 10 minutes, and even thereafter the concentration is very low. The rate of accumulation roughly parallels that of the plasma indicating no special affinity of the brain for the drug.
(c) The adrenals and liver show a marked ability to accumulate methadone∗ at a rate in excess of that shown by either the cerebrum or plasma.
(d) There was no activity in the sciatic nerve within the period studied.
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