Abstract
Summary
Dogs subjected to both chloroform intoxication and acute massive plasmapheresis reveal changes in prothrombin concentration which rather conclusively indicate that no significant reserve stores of prothrombin exist. The stabilization of prothrombin at subnormal levels, as well as the rate of recovery of prothrombin, represents, instead, a balanced equilibrium between production and utilization. The data also substantiate the impression that hepatotoxic injury, with a concomitant decrease in prothrombin concentration, is a gradual progressive phenomenon.
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