Abstract
Summary
The preparation and properties of gelatin films, which resisted water solution in varying degrees, have been described.
These films, although water insoluble, have been shown to be digested in different lengths of time when subjected to proteolytic enzymes in vitro in a standardized assay.
Some of the altered gelatin films were implanted into muscle areas of albino rats. Upon visual inspection they were found to be absorbed at the recorded intervals, with no evidence of untoward tissue reaction. The data indicate that the biologic absorption time can be roughly predicted from in vitro digestion results; as the in vitro times become greatly prolonged, however, a comparable resistance to biologic absorption is not seen.
Cellophane implants were not absorbed but at the eleventh week were encapsulated in a thin membranous capsule.
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