Veratramine,an Antagonist to the Cardioaccelerator Action of Epinephrine.

Abstract

Hitherto studied adrenolytic substances prevent or abolish the vasomotor effect of epinephrine but are unable to modify its effect upon heart rate. Consistent results, obtained in 10 heart-lung preparations of the dog and in 4 spinal cats, show that veratramine,* ^1,2 one of the veratrum alkaloids recently reviewed,³ prevents or abolishes the cardioaccelerator action of epinephrine in doses which do not abolish its vasopressor effect.