Abstract
Summary
Syngenesiotransplants of ovaries made at one month of age caused mammary cancer in 5% of castrate male mice of strain A. The tumor incidence rose to 32.5%, if anterior hypophyses were grafted together with ovaries. Transplantation of anterior hypophyses alone failed to produce breast cancer. No mammary tumors occurred in castrates into which ovaries, anterior hypo- physes alone or anterior hypophyses in combination with ovaries were grafted at 7 months of age. Thus in male mice, an age factor which is independent of the testicle operates in the production of breast cancer by ovarian and anterior hypophyseal grafts.
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