Abstract
Summary
1. A serial tube-dilution method of determinations of aureomycin concentrations in body fluids using an hemolytic streptococcus as the test organism is described.
2. Serum levels of aureomycin ranged from 0.3 μg to 2.5 μg during a 6-hour period following the initial oral dose of 1 g.
3. Serum levels or aureomycin following doses of 1 g on subsequent days in patients receiving continuous therapy ranged from 0.3 μg to 20 μg during a 6-hour period.
4. Serum concentrations of aureomycin following the intravenous administration of 50 mg ranged from 0.6 to 5 μg 5 minutes after injection and declined gradually over a 6-hour period.
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