Comparison of Atropine and Tripelennamine in Treatment of Peptone Shock in Dogs

Abstract

Conclusions

1) One gram/kg body weight of Witte's peptone administered intravenously in a 20% solution, proved fatal in dogs anesthetized with sodium pentobarbital.

2) Atropine sulfate, 2.0 mg/kg prevented death from peptone.

3) Pyribenzamine, 10.0 mg/kg, afforded better protection than atropine as determined by rapidity of recovery of blood pressure.

4) The rapidity of recovery of blood pressure was not greater in those animals receiving both pyribenzamine and atropine than in those receiving pyribenzamine alone.

5) These findings support the theory that acetylcholine is concerned in the production of peptone shock, although histamine plays a more important role.