Abstract
Conclusions
1. The observation that a histamine derivative appears in the urine of dog and man after oral histamine administration is confirmed.
2. The histamine derivative can be effectively separated from histamine by paper chromatography.
3. The histamine derivative is identical with acetyl histamine as shown by paper chroma tography.
4. Acetyl histamine is readily formed from histamine added to feces of dog and man.
5. It is suggested that histamine is acetylated in the intestinal contents to acetyl histamine which is partially absorbed from the intestinal tract and excreted in the urine as well as in the feces.
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