Abstract
In November of last year we injected into the femoral vein of a dog 5 c.c. of the defibrinated centrifuged blood of a rabbit, which had previously been injected subdurally with a fixed seven days'virus of hydrophobia.
The arterial pressure taken with a mercurial manometer from the carotid artery showed a marked depression. Further trials of the same experiment gave the same results. Since these experiments, we have been able to demonstrate that the blood serum of rabbits, which have been infected with hydrophobia 72 and 48 hours previously as described, possess this depressor substance, and even in the serum of a rabbit which had been infected only 24 hours previous to bleeding, there was a decided indication of a depressor substance.
If the blood of a rabbit suffering from hydrophobia be run into absolute alcohol and the filtered alcoholic extract be evaporated on the water-bath or in vacuo, there will be found a water-soluble substance which causes a marked arterial depression. We obtained this depressor effect in the alcoholic extract also from the blood of the rabbits injected only 48 and 24 hours respectively before the test.
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