Abstract
While it is easy to produce experimentally an arterial lesion in the rabbit, it is extremely difficult to repeat the same in the dog. All attempts to produce arterial lesions in normal dogs, by injection of adrenalin or other similar substances, failed. Carrel and Guthrie, Stich and others stated that the walls of a segment of a vein implanted in an artery undergo certain changes which consist in a hyperplasia of the connective tissue of interstitia, and in an increase of the number of the muscular and elastic fibers of the media. But it is hardly possible to draw a correct conclusion from this method of experimentation, since such a segment is completely severed from its vascular and nerve connections.
Since the majority of writers on arteriosclerosis maintain that the mechanical increase of blood pressure is the most important factor in the causation of the disease, we endeavored in our experiments to increase the blood pressure within the lumen of a vein by the following method:
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