Abstract
Summary
Allergic encephalitis in guinea pigs was produced by inoculation of brain tissue derived from 5 different mammalian species. Dilutions of phenolized rabies vaccines combined with adjuvants also caused paralysis of the inoculated animals. The majority of the guinea pigs previously sensitized by subcutaneous injection of brain tissue incorporated into adjuvants died after the intracerebral inoculation of homologous brain tissue (but not when brain tissue of cavian origin was used). Pathologic changes observed in the animals were described. Complement-fixing antibrain antibodies were found in sera of guinea pigs inoculated subcutaneously with brain tissue. Intracerebral reinoeulation of these animals usually resulted in the rise of titer of the humoral antibrain antibodies.
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