Incidence of Mammary Tumors in Castrate and Non-Castrate Male Mice Bearing Ovarian Grafts. ∗

Abstract

Conclusions

Castrate male mice of the F₁ hybrid generation between the A and Z stocks bearing subcutaneous ovarian grafts developed mammary cancer more readily than do virgin female mice of this cross. Only 1 of 39 non-castrate males bearing ovarian grafts develop mammary carcinoma as little mammary development occurred. Additional experiments seemed to indicate that the ovaries in the non-castrate male mice were producing an appreciable amount of estrogen although measurably less than those carried in castrate males. There appeared, also, to be an antagonism between estrogens and androgens as far as stimulation of the vaginal and mammary epithelium is concerned. Granulosa cell tumors occasionally occurred in ovarian grafts of old male and female mice of this hybrid cross.