Abstract
Conclusion
The least amount of streptomycin that will inhibit the growth of the organism has been found by a similar procedure to be 0.075 γ/cc. Therefore, the serum streptomycin level is equal to 0.075 × Serum Dilution × Total Volume of Medium × 2. For example, if the endpoint of the assay is tube 5, which contains a serum diluted to 1: 16, the serum streptomycin level is 0.075 × 16 × 5 × 2 = 12 γ/cc. With this simple method, a serum level of 0.75 γ/cc to 48 γ/cc can be determined This range embraces the serum levels that are commonly encountered in streptomycin therapy. However, with slight modifications, such as using undiluted serum as the first tube and diluting the serum further, one is able to determine a streptomycin level from 0.375 γ/c to any level higher than 48 γ/cc.
Get full access to this article
View all access options for this article.