Effect of Dibenamine on Renal Hypertension in Rats. ∗

Abstract

Summary

1. Oral administration of 100 mg/kg Dibenamine causes some reduction of blood pressure in both normotensive and renal hypertensive rats. The fall is usually greater and more prolonged in hypertensive animals. 2. The fall in blood pressure is due to the adrenergic blocking action of Dibenamine and does not follow the administration of larger doses of the adrenergically inactive N,N-dibenzyl-ethanolamine. 3. In 65% of the hypertensive animals tested, repeated daily doses of Dibenamine produced a persistent, but somewhat variable lowering of the blood pressure. The pressure usually returned to pretreatment levels in 3 to 4 days after the last administration of Dibenamine. 4. The bearing of these data on postulated neurogenic factors in experimental renal hypertension is discussed, and it is concluded that they do not support the contention that a greater neurogenic factor is involved in late than in early renal hypertension.